研究業績

  1. ホーム
  2. 研究業績
  1. Cheriyan J, Kaushik MK, Ferreira AN, Sheets PL. Specific Targeting of the Basolateral Amygdala to Projectionally Defined Pyramidal Neurons in Prelimbic and Infralimbic Cortex.
    eNeuro. 2016 Mar 21;3(2). pii: ENEURO.0002-16.2016. doi: 10.1523/ENEURO.0002-16.2016
  2. Chen L, Yin D, Wang TX, Guo W, Dong H, Xu Q, Luo YJ, Cherasse Y, Lazarus M, Qiu ZL, Lu J, Qu WM, Huang ZL. Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice.
    Neuropsychopharmacology. 2016 Jan 22. doi: 10.1038/npp.2016.13
  3. Oishi Y, Takata Y, Taguchi Y, Kohtoh S, Urade Y, Lazarus M. Polygraphic Recording Procedure for Measuring Sleep in Mice.
    J Vis Exp. 2016 Jan 25;(107). doi: 10.3791/53678
  4. Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, Urade Y. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice.
    Mol Nutr Food Res. 2015 Oct;59(10):2087-93. doi: 10.1002/mnfr.201500082
  5. Monoi N, Matsuno A, Nagamori Y, Kimura E, Nakamura Y, Oka K, Sano T, Midorikawa T, Sugafuji T, Murakoshi M, Uchiyama A, Sugiyama K, Nishino H, Urade Y. Japanese sake yeast supplementation improves the quality of sleep: a double-blind randomised controlled clinical trial.
    J Sleep Res. 2015 Sep 10. doi: 10.1111/jsr.12336
  6. Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T. PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.
    Nat Commun. 2015 Jul 10;6:7514. doi: 10.1038/ncomms8514
  7. Oishi Y, Yoshida K, Scammell TE, Urade Y, Lazarus M, Saper CB. The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep.
    Brain Behav Immun. 2015 Jul;47:172-7. doi: 10.1016/j.bbi.2014.11.019
  8. Wang YQ, Takata Y, Li R, Zhang Z, Zhang MQ, Urade Y, Qu WM, Huang ZL. Doxepin and diphenhydramine increased non-rapid eye movement sleep through blockade of histamine H1 receptors.
    Pharmacol Biochem Behav. 2015 Feb;129:56-64. doi: 10.1016/j.pbb.2014.12.002
  9. Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination.
    Nat Neurosci. 2014 Dec;17(12):1682-92. doi: 10.1038/nn.3857.
  10. Nakahara K, Fujiwara Y, Tsukahara T, Yamagami H, Tanigawa T, Shiba M, Tominaga K, Watanabe T, Urade Y, Arakawa T. Acid reflux directly causes sleep disturbances in rat with chronic esophagitis.
    PLoS One. 2014 Sep 12;9(9):e106969. doi: 10.1371/journal.pone.0106969.
  11. Inui T, Mase M, Shirota R, Nagashima M, Okada T, Urade Y. Lipocalin-type prostaglandin D synthase scavenges biliverdin in the cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage.
    J Cereb Blood Flow Metab. 2014 Sep;34(9):1558-67. doi: 10.1038/jcbfm.2014.127.
  12. Fujimori K, Urade Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins.
    Methods Mol Biol. 2014;1164:177-96. doi: 10.1007/978-1-4939-0805-9_15.
  13. Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T. Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice.
    Cancer Res. 2014 Jun 1;74(11):3011-9. doi: 10.1158/0008-5472.CAN-13-2792.
  14. Uchiyama N, Matsuda S, Kawamura M, Shimokawa Y, Kikura-Hanajiri R, Aritake K, Urade Y, Goda Y. Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products.
    Forensic Sci Int. 2014 Oct;243:1-13. doi: 10.1016/j.forsciint.2014.03.013.
  15. Nishida N, Nagata N, Toda H, Jingami N, Uemura K, Ozaki A, Mase M, Urade Y, Matsumoto S, Iwasaki K, Ishikawa M. Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus.
    Fluids Barriers CNS. 2014 Apr 15;11(1):9. doi: 10.1186/2045-8118-11-9.
  16. Tippin BL, Kwong AM, Inadomi MJ, Lee OJ, Park JM, Materi AM, Buslon VS, Lin AM, Kudo LC, Karsten SL, French SW, Narumiya S, Urade Y, Salido E, Lin HJ. Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR.
    Cancer Med. 2014 Aug;3(4):1041-51. doi: 10.1002/cam4.251.
  17. Liu YY, Yin D, Chen L, Qu WM, Chen CR, Laudon M, Cheng NN, Urade Y, Huang ZL. Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain.
    Psychopharmacology (Berl). 2014 Oct;231(20):3973-85. doi: 10.1007/s00213-014-3530-5.
  18. Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells.
    Elife. 2014 Mar 25;3:e02172. doi: 10.7554/eLife.02172.
  19. Izumi Y, Aritake K, Urade Y, Fukusaki E. Practical evaluation of liquid chromatography/tandem mass spectrometry and enzyme immunoassay method for the accurate quantitative analysis of prostaglandins.
    J Biosci Bioeng. 2014 Jul;118(1):116-8. doi: 10.1016/j.jbiosc.2013.12.022.
  20. Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor.
    Psychopharmacology (Berl). 2014 Jul;231(14):2825-37. doi: 10.1007/s00213-014-3445-1.
  21. Zhang JP, Xu Q, Yuan XS, Cherasse Y, Schiffmann SN, de Kerchove d'Exaerde A, Qu WM, Urade Y, Lazarus M, Huang ZL, Li RX. Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation.
    Front Neuroanat. 2013 Dec 10;7:43. doi: 10.3389/fnana.2013.00043.
  22. Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K. δ-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice.
    Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72. doi: 10.1152/ajpregu.00405.2013.
  23. Kaushik MK, Aritake K, Kamauchi S, Hayaishi O, Huang ZL, Lazarus M, Urade Y. Prostaglandin D(2) is crucial for seizure suppression and postictal sleep.
    Exp Neurol. 2014 Mar;253:82-90. doi: 10.1016/j.expneurol.2013.12.002.
  24. Xu Q, Xu XH, Qu WM, Lazarus M, Urade Y, Huang ZL. A mouse model mimicking human first night effect for the evaluation of hypnotics.
    Pharmacol Biochem Behav. 2014 Jan;116:129-36. doi: 10.1016/j.pbb.2013.11.029.
  25. Sarashina H, Tsubosaka Y, Omori K, Aritake K, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H, Murata T. Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation.
    J Immunol. 2014 Jan 1;192(1):459-65. doi: 10.4049/jimmunol.1302080.
  26. Zhang JP, Xu Q, Yuan XS, Cherasse Y, Schiffmann SN, de Kerchove d'Exaerde A, Qu WM, Urade Y, Lazarus M, Huang ZL, Li RX. Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation.
    Front Neuroanat. 2013 Dec 10;7:43. doi: 10.3389/fnana.2013.00043
  27. Xu XH, Qu WM, Bian MJ, Huang F, Fei J, Urade Y, Huang ZL. Essential roles of GABA transporter-1 in controlling rapid eye movement sleep and in increased slow wave activity after sleep deprivation.
    PLoS One. 2013 Oct 14;8(10):e75823. doi: 10.1371/journal.pone.0075823.
  28. Yamamoto K, Suzuki M, Higashiura A, Aritake K, Urade Y, Uodome N, Hossain T, Nakagawa A. New insights into the catalytic mechanism of Bombyx mori prostaglandin E synthase gained from structure-function analysis.
    Biochem Biophys Res Commun. 2013 Nov 1;440(4):762-7. doi: 10.1016/j.bbrc.2013.10.001.
  29. Xu XH, Qiu MH, Dong H, Qu WM, Urade Y, Huang ZL. GABA transporter-1 inhibitor NO-711 alters the EEG power spectra and enhances non-rapid eye movement sleep during the active phase in mice.
    Eur Neuropsychopharmacol. 2014 Apr;24(4):585-94. doi: 10.1016/j.euroneuro.2013.09.002.
  30. Yamamoto K, Higashiura A, Suzuki M, Aritake K, Urade Y, Uodome N, Nakagawa A. Crystal structure of a Bombyx mori sigma-class glutathione transferase exhibiting prostaglandin E synthase activity.
    Biochim Biophys Acta. 2013 Jun;1830(6):3711-8. doi: 10.1016/j.bbagen.2013.02.021.
  31. Xu XH, Qu WM, Bian MJ, Huang F, Fei J, Urade Y, Huang ZL. Essential Roles of GABA Transporter-1 in Controlling Rapid Eye Movement Sleep and in Increased Slow Wave Activity after Sleep Deprivation.
    PloS ONE 2013, 8(10): e75823.
  32. Chen CR, Yang SR, Liu YY, Qu WM, Urade Y, Huang ZL. Roles of adrenergic α1 and dopamine D1 and D2 receptors in the mediation of the desynchronization effects of modafinil in a EEG synchronization model.
    PloS ONE 2013, 8(10): e76102.
  33. Kallweit U, Aritake K, Bassetti CL, Blumenthal S, Hayaishi O, Linnebank M, Baumann CR, Urade Y. Elevated CSF histamine levels in multiple sclerosis patients.
    Fluids Barriers CNS, 2013, 10 (1), 19. 3.
  34. Lazarus M, Chen JF, Urade Y, Huang ZL. Role of the basal ganglia in the control of sleep and wakefulness.
    CurrOpinNeurobiol, 2013, DOI:10.1016 j.conb.2013.02.001.
  35. Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H. Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement.
    ProcNatlAcadSci U S A, 2013, 110 (13), 5205-10.
  36. Nakagawa T, Takeuchi A, Kakiuchi R, Lee T, Yagi M, Awano H, Iijima K, Takeshima Y, Urade Y. Matsuo M. A prostaglandin D2 metabolite is elevated in the urine of Duchenne muscular dystrophy patients and increases further from 8 years old.
    ClinChimActa, 2013, 423, 10-4.
  37. Sunagawa G, Sei H, Shimba S, Urade Y. Ueda, H. R., FASTER: an unsupervised fully automated sleep staging method for mice.
    Genes Cells 2013, 18 (6), 502-18.
  38. Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Watanabe K, Hirai H, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
    Nat Immunol, 2013, 14 (6), 554-63.
  39. Wang Q, Yue XF, Qu WM, Tan R, Zheng P, Urade Y, Huang ZL. Morphine inhibits sleep-promoting neurons in the ventrolateral preoptic area via mu receptors and induces wakefulness in rats.
    Neuropsychopharmacology, 2013, 38 (5), 791-801.
  40. Yasuda K, Cline C, Vogel P, Onciu M, Fatima S, Sorrentino BP, Thirumaran R K, Ekins S, Urade Y, Fujimori K, Schuetz EG. Drugtransporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier.
    Drug Metab Dispos, 2013, 41 (4), 923-31.
  41. Lazarus M, Huang ZL, Lu J, Urade Y, Chen JF. How do the basal ganglia regulate sleep-wake behavior?
    Trends Neurosci, 2012, 35:723-732.
  42. Wang YQ, Tu ZC, Xu XY, Li R, Qu WM, Urade Y, Huang ZL. Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats.
    J Neurochem, 2012, 120:314-324.
  43. Uchiyama N, Kikura-Hanajiri R, Matsumoto N, Huang ZL, Goda Y, Urade Y. Effects of synthetic cannabinoids on electroencephalogram power spectra in rats.
    Forensic Sci Int, 2012, 215:179-183.
  44. Qu WM, Yue XF, Sun Y, Fan K, Chen CR, Hou YP, Urade Y, Huang ZL. Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice.
    Br J Pharmacol, 2012, 167:587-598.
  45. Qiu MH, Liu W, Qu WM, Urade Y, Lu J, Huang ZL. The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal.
    PLoS One, 2012, 7:e45471.
  46. Masaki M, Aritake K, Tanaka H, Shoyama Y, Huang ZL, Urade Y. Crocin promotes non-rapid eye movement sleep in mice.
    Mol Nutr Food Res, 2012, 56:304-308.
  47. Lu J, Katano T, Nishimura W, Fujiwara S, Miyazaki S, Okasaki I, Aritake K, Urade Y, Minami T, Ito S. Proteomic analysis of cerebrospinal fluid before and after intrathecal injection of steroid into patients with postherpetic pain.
    Proteomics, 2012, 12:3105-3112.
  48. Liu Z, Xu XH, Liu TY, Hong ZY, Urade Y, Huang ZL, Qu WM. Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice.
    CNS Neurosci Ther, 2012, 18:623-630.
  49. Kaneko K, Lazarus M, Miyamoto C, Oishi Y, Nagata N, Yang S, Yoshikawa M, Aritake K, Furuyashiki T, Narumiya S, Urade Y, Ohinata K. Orally administered rubiscolin-6, a delta opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice.
    Mol Nutr Food Res, 2012, 56:1315-1323.
  50. Chihara Y, Chin K, Aritake K, Harada Y, Toyama Y, Murase K, Yoshimura C, Hitomi T, Oga T, Mishima M, Urade Y. A urine biomarker for severe OSA patients: lipocaline-type prostaglandin D synthase.
    Eur Respir J, 2012. DOI: 10.1183/09031936.00133512
  51. Chen CR, Zhou XZ, Luo YJ, Huang ZL, Urade Y, Qu WM. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice.
    Neuropharmacology, 2012, 63:1191-1199.
  52. Huang ZL, Urade Y, Hayaishi O. The role of adenosine in the regulation of sleep.
    Curr Top Med Chem, 2011, 11:1047-1057.
  53. Smith WL, Urade Y, Jakobsson PJ. Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.
    Chem Rev, 2011, 111:5821-5865.
  54. Urade Y, Hayaishi O. Prostaglandin D2 and sleep/wake regulation.
    Sleep Med Rev, 2011, 15:411-418.
  55. Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T. Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
    Am J Pathol, 2011, 179:302-314.
  56. Shinozawa T, Urade Y, Maruyama T, Watabe D. Tetranor PGDM analyses for the amyotrophic lateral sclerosis: positive and simple diagnosis and evaluation of drug effect.
    Biochem Biophys Res Commun, 2011, 415:539-544.
  57. Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Uneo S, Koyasu T, Matsui R, Cherasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T. miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression.
    Nat Neurosci, 2011, 14:1125-1134.
  58. Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H. Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma.
    Proc Natl Acad Sci U S A, 2011, 108:19802-19807.
  59. Lazarus, M., Shen, H.Y., Cherasse, Y., Qu, W.M., Huang,Z.L., Bass, C., Winsky-Sommerer, R., Semba, K., Fredholm, B., Boison, D., Hayaishi, O., Urade, Y., and Chen, J.F. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens,
    J Neurosci (2011) Jul 6;31(27):10067-75. doi: 10.1523/JNEUROSCI.6730-10.2011
  60. Chen, C., Tan, R., Qu W.M., Wu, Z., Wang, Y., Urade, Y. and Huang, Z.L. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts anti-epileptic effects via GABA-benzodiazepine receptor complex in mice,
    Br J Pharmacol (2011) Nov;164(5):1534-46. doi: 10.1111/j.1476-5381.2011.01456.x
  61. Yan, M.M., Xu, X.H., Huang, Z.L., Yao, M.H., Urade, Y., and Qu, W.M. Selection of optimal epoch duration in assessment of rodent sleep-wake profiles,
    Sleep Biol Rhythm (2011) 9: 46–55.
  62. Kuroda E., Ishii KJ, Uematsu S., Ohata K., Coban C., Akira S., Aritake, K., Urade, Y., Morimoto, and Y. Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms.
    Immunity (2011) 34:514-26.
  63. Huang Z.L., Urade Y., Hayaishi O. The role of adenosine in the regulation of sleep,
    Curr Top Med Chem (2011) 11:1047-57.
  64. Ogasawara M., Hirose A., Ono M., Aritake K., Nozaki Y., Takahashi M., et al. A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet.
    Liver Int, (2011) 31:542-51.
  65. Nagata, N., Kusakari, Y., Fukunishi, Y., Inoue, T., and Urade, Y. Catalytic mechanism of the primary human prostaglandin F(2alpha) synthase, aldo-keto reductase 1B1 – prostaglandin D(2) synthase activity in the absence of NADP(H),
    Febs J (2011) 278: 1288-1298.
  66. Redensek, A., Rathore, K. I., Berard, J. L., Lopez-Vales, R., Swayne, L. A., Bennett, S. A., Mohri, I., Taniike, M., Urade, Y., and David, S. Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury,
    Glia (2011) 59: 603-614.
  67. Tanaka, H., Tsurumura, T., Aritake, K., Furubayashi, N., Takahashi, S., Yamanaka, M., Hirota, E., Sano, S., Sato, M., Kobayashi, T., Tanaka, T., Inaka, K., and Urade, Y. Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment,
    J Synchrotron Radiat (2011) 18: 88-91.
  68. Yamaguchi, K., Okamoto, N., Tokuoka, K., Sugiyama, S., Uchiyama, N., Matsumura, H., Inaka, K., Urade, Y., and Inoue, T. Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi,
    J Synchrotron Radiat (2011) 18: 66-69.
  69. Kunori, S., Matsumura, S., Okuda-Ashitaka, E., Katano, T., Audoly, L. P., Urade, Y. and Ito, S. A novel role of prostaglandin E(2) in neuropathic pain: blockade of microglial migration in the spinal cord,
    GLIA (2011) 59: 208-218.
  70. Matsumoto,T., Eguchi, Y., Oda, H., Yamane, T., Tarutani, Y., Ozawa, T., Hayashi, H., Nakae, I., Horie, M., and Urade, Y. Lipocalin-type Prostaglandin D Synthase is Associated with Coronary Vasospasm and Vasomotor Reactivity in Response to Acetylcholine,
    Circ J(2011) 75: 897-904.
  71. Aritake, K., Koh, C. S., Inoue, A., Yabuuchi, F., Kitagaki, K., Ikoma, Y., and Hayashi, S. Effects of human recombinant-interferon beta in experimental autoimmune encephalomyelitis in guinea pigs,
    Pharm Biol (2010) 48, 1273-1279.
  72. Fujitani, Y., Aritake, K., Kanaoka, Y., Goto, T., Takahashi, N., Fujimori, K., and Kawada, T. Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo,
    Febs J (2010) 277, 1410-1419.
  73. Gautron, L., Lazarus, M., Scott, M. M., Saper, C. B., and Elmquist, J. K. Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach,
    J Comp Neurol (2010) 518, 2090-2108.
  74. Devidze, N., Fujimori, K., Urade, Y., Pfaff, D. W., and Mong, J. A. Estradiol regulation of lipocalin-type prostaglandin D synthase promoter activity: evidence for direct and indirect mechanisms,
    Neurosci Lett (2010) 474, 17-21.
  75. Fujimori, K., Ueno, T., Nagata, N., Kashiwagi, K., Aritake, K., Amano, F., and Urade, Y. Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase,
    J Biol Chem (2010) 285, 8880-8886.
  76. Miyamoto, Y., Nishimura, S., Inoue, K., Shimamoto, S., Yoshida, T., Fukuhara, A., Yamada, M., Urade, Y., Yagi, N., Ohkubo, T., and Inui, T. Structural analysis of lipocalin-type prostaglandin D synthase complexed with biliverdin by small-angle X-ray scattering and multi-dimensional NMR,
    J Struct Biol (2010) 169, 209-218.
  77. Qu, W. M., Xu, X. H., Yan, M. M., Wang, Y. Q., Urade, Y., and Huang, Z. L. Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice,
    J Neurosci (2010) 30, 4382-4389.
  78. Shimura, C., Satoh, T., Igawa, K., Aritake, K., Urade, Y., Nakamura, M., and Yokozeki, H. Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin,
    Am J Pathol (2010) 176, 227-237.
  79. Takahashi, S., Tsurumura, T., Aritake, K., Furubayashi, N., Sato, M., Yamanaka, M., Hirota, E., Sano, S., Kobayashi, T., Tanaka, T., Inaka, K., Tanaka, H., and Urade, Y. High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors,
    Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 66, 846-850.
  80. Uchida, Y., Urade, Y., Mori, S., and Kohzuma, T. UV resonance Raman studies on the activation mechanism of human hematopoietic prostaglandin D(2) synthase by a divalent cation, Mg(2+),
    J Inorg Biochem (2010) 104, 331-340.

Book

  1. Hayaishi, O. &Urade, Y. (2008) Prostaglandins and sleep/wake regulation.
    Neurochemistry of Sleep and Wakefulness (ed. by Monti, J.M., Pandi-Perumal, S.R., Sinton, C.M.), Cambridge University Press, Cambridge, UK, Chapter 13, 363-386
  2. Urade, Y. &Hayaishi, O. (2008) Prostaglandins and sleep/wake regulation.
    Sleep Disorders: Diagnosis and Therapeutics (ed. Pandi-Perumal, S.R., Verster, J. C., Monti, J.M., Lader, M., Langer, S.Z.), informa healthcare, UK, Chapter 24, 246-258.

Book

  1. Urade Y, Hayaisi O. Crucial role of prostaglandin D₂ and adenosine in sleep regulation: experimental evidence from pharmacological approaches to gene-knockout mice.
    Future Neurology (2010) 5(3): 363-37
  2. Urade Y. Molecular mechanism of sleep-wake regulation.
    Hirosaki Med. J (2010) 61(Suppl.): S164-S173

関連サイト